PHARMACOLOGICAL PROPERTIES OF PEMPIDINE (1:2:2: 6: 6-PENTAMETHYLPIPERIDINE), A NEW GANGLION-BLOCKING COMPOUND

Pharmacological properties of beta-adrenoceptor blocking drugs

Pharmacological Application of Antiradical Compound Properties

The reactive species are part of normal human metabolism and are involved in many physiological mechanisms. However, when reactive species are overproduced and antioxidant defenses are insufficient to control oxidation, an unbalance can occur, leading to cellular oxidative damage. This injury has been associated with many diseases including inflammation, cancer, cardiovascular disease, diabetes...

Synthesis, characterization and pharmacological evaluation of 1-(2-chloro-6-fluorophenyl)-5-methylindolin-2-one: a new anti-inflammatory compound with reduced gastric ulceration properties.

The new compound 1-(2-chloro-6-fluorophenyl)-5-methylindolin-2-one (1), designed using the prodrug approach, was easily obtained in 85% yield and characterized by nuclear magnetic resonance, elemental analysis, mass spectrometry and infrared spectroscopy. The lactam 1 showed anti-inflammatory and analgesic activity comparable to that of the COX-2 inhibitor lumiracoxib, without gastro-ulceration...

The ganglion-blocking properties of hexamethylene bisdialkylsulphonium salts.

The pharmacological properties of tertiary sulphonium salts appear to be similar to those of quaternary ammonium salts. The trimethyl+ sulphonium ion, Me3S, resembles the tetramethyl+ ammonioum ion, Me N in its ability to paralyse the frog sartorius preparation (Ing and Wright, 1933): decamethylene bisdimethylsulphonium + + Me2S-(CH2)10-SMe2, resembles decamethonium, + + Me3N-(CH2)0-NMe3, in it...

The Effect of Hydrogen Bonding and π–π Stacking to Stabilization of 3D Networks of a New Proton Compound, (a-6-mpyH)(Hpyzd) H2O

A new proton transfer compound, formulated as (Hamp-6-pic)(Hpyzd) ∙H2O (1), has been synthesized from the reaction of pyrazine-2,3-dicarboxylic acid (H2pyzd)  and 2-amino-6-methyl pyridine (amp-6-pic), in 1:1 molar ratio. Extensive O−H×××O, N−H×××N and O−H×××O hydrogen bonds involving (Hamp-6-pic)+ cation, (Hpyzd)- anion and co-crystal water molecule٫ static electronic٫ and π…π stacking interac...